The Position

We are seeking a Director, FP&A to serve as a strategic finance partner to our R&D organization. In this highly visible role, you will support critical investment decisions across our development portfolio by delivering financial insights, forecasting, and decision support.

You’ll work closely with R&D and finance leadership to translate scientific and clinical strategies into actionable financial plans, helping ensure resources are deployed effectively across programs.

This role reports to the Sr. Director of FP&A and follows a hybrid scheduled of two-to-three days per week in office.

The Impact You’ll Have

Strategic Partnership & Decision Support

Partner with R&D leadership and project teams to develop portfolio and program-level financial plans
Lead scenario modeling, cost-benefit analyses, and vendor investment decisions
Support clinical program investment decisions and other high-priority strategic initiatives

Financial Planning & Analysis

Deliver accurate and timely forecasts, budgets, and long-range plans for R&D functions
Prepare and present financial analyses to senior leadership, including materials for Board meetings
Provide variance analysis and actionable insights to inform decision-making

Cross-Functional Collaboration

Partner closely with Accounting to align budget vs actuals, including accruals, coding, and variance reporting
Collaborate with functional stakeholders to translate scientific and operational plans into financial outcomes

Process Improvement & Systems

Drive improvements in FP&A processes, reporting, and forecasting accuracy
Partner with the Head of FP&A to enhance and automate allocation methodologies across programs and indications

As a Director, we also expect our leaders to demonstrate the following Leadership Competencies:

Communication and Influence
- Builds communication channels across Maze for sharing information.
- Influences Senior Management decisions through persuasive arguments.
- Respectfully addresses differing opinions leading to support of decisions.
Teamwork and Collaboration
- Champions partnerships and connections across Maze.
- Proactively addresses issues that could result in breakdown of team relationships.
- Spotlights team and individual contributions in public forums.
Execution and Results
- Addresses gaps and leverages strengths to get best results.
- Maintains a steadying presence and clarifies priorities during change.
- Anticipates and removes barriers that put functional/corporate goals at risk.
Develop Others and Self
- Remove barriers to staff development and empowers them to make their own decisions.
- Stays current on industry trends and keeps direct-reports prepared and responsive.

What We’re Looking For

Experience & Background

Bachelor’s degree in Finance, Accounting, Economics, or related field; MBA or equivalent experience preferred.
10+ years of experience in the pharmaceutical or biotech industry, including significant FP&A experience
Experience supporting R&D or development organizations strongly preferred
Clinical trial forecasting and accruals experience preferred

Technical & Analytical Skills

Advanced proficiency in Excel and PowerPoint
Experience with financial systems such as NetSuite, Coupa, and Anaplan, or similar tools
Strong financial modeling and forecasting capabilities, including ad hoc analysis

Business Partnership & Communications

Proven ability to build strong relationships and influence cross-functional stakeholders
Ability to translate complex scientific and strategic concepts into clear financial insights
Excellent written and verbal communication

Execution & Mindset

Highly organized with the ability to manage multiple priorities and meet deadlines
Detail-oriented and solution-driven, with a focus on continuous improvement
Collaborative mindset with a focus on improving efficiency and effectiveness
Interest in exploring applications of AI to enhance FP&A processes

This role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters two-to-three days per week.

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease. 

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $227,000 to $277,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

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