About Us…

Obsidian Therapeutics is pioneering engineered cell and gene therapies to deliver transformative outcomes for patients. Obsidian’s programs apply our cytoDRiVE® technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Obsidian’s lead program is currently in clinical development for the treatment of patients with metastatic melanoma and non-small cell lung cancer.

We’re proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our Research team is based in the heart of Cambridge, MA, and Technical Operations team is based in our purpose built facility in Bedford, MA. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.

Our Opportunity...

We are looking for a highly motivated Senior Accountant with a strong background in general accounting. As a key contributor within the Finance team, you'll own several key areas of the monthly close process and support the company’s financial operations with accuracy, efficiency, and strong attention to detail, helping to drive the development of our first clinical stage autologous cell therapy program targeting solid tumors.

You’ll lead and execute core accounting activities including cash reconciliations, accruals, accounts payable, payroll accounting, and other month-end close responsibilities, ensuring timely and accurate financial reporting in a fast-paced and growing biotechnology company environment.

As a member of our Finance team, you will be a vital part of a highly collaborative group working to unlock the promise of precision cell therapy for patients, starting with our lead program amsoki-cel (OBX-115), a novel engineered tumor-infiltrating lymphocyte (TIL) cell therapy that uses our proprietary cytoDRiVE® platform. This is a unique opportunity to be a valuable contributor in a well-funded clinical company with field-leading advisors, best-in-class partners, and an experienced team.

This is a Hybrid role based out of our Cambridge, MA location until Q2, 2027 when our Bedford, MA office space expands to become our single MA location

You Will...

Core responsibilities

Execute month-end, quarter-end and year-end close processes
Prepare journal entries and reconciliations for assigned areas of ownership
Train and provide cross functional support related to the company’s procure-to-pay policies and procedures
Responsible for invoice entry and weekly payment runs
Manage Travel & Expense reporting system (Concur), process (including policy adherence), and journal entries
Execute payroll processing, reporting & accounting
Register & Manage State Withholding Accounts & State Tax Compliance
Manage day-to-day cash and treasury operations, including monitoring bank balances, cash positioning, transfers and bank reconciliations.
Prepare and maintain short-term cash forecasts, partnering with Finance to ensure adequate liquidity for payroll, operating expenses, clinical activities, and other anticipated cash needs.
Ensure compliance with applicable accounting standards, regulatory requirements, and internal controls
Assist with external audits, including preparations of audit schedules and documentation
Identify and implement process improvements to enhance efficiency and accuracy in financial operation

You Bring...

Core Qualifications

Bachelor’s degree in accounting, Finance or related field.
5-7+ years of progressive accounting experience, preferably in the biotechnology, pharmaceutical, or life sciences industry.
Strong knowledge of GAAP, and demonstrated ability to research, analyze, document, and apply accounting guidance to non-routine transactions.
Demonstrated ability to independently execute month-end, quarter-end, and year-end close processes and produce accurate, audit-ready financial information.
Strong understanding of internal controls over financial reporting, with hands-on experience executing and documenting SOX controls and supporting external audits.
Hands-on experience with treasury and cash management, including bank administration, cash forecasting, payments, reconciliations, and investment activities.
Proficiency in ERP systems, advanced Excel skills, and an ability to rapidly learn new systems.
Excellent planning, coordination, and time management skills 
Excellent oral, written, and visual communication skills. You listen to understand and communicate effectively and persuasively with partners, colleagues, and leadership. 
Ability to build and maintain productive relationships across the organization  
Collaborative and accountable – recognizes success requires teamwork and interdisciplinary thinking; shares feedback and ideas to facilitate better outcomes
Self-motivated, with a proven ability to meet objectives, timelines, and high standards managing multiple responsibilities in parallel.  
Flexible - adapts to change in a fast paced, rapidly developing environment
Curious and humble – seeks and welcomes input/expertise of others, continuous learner
Tenacious and resilient – is not easily overwhelmed by challenges, delivers on commitments, operates with urgency.

Bonus Qualifications

Experience with payroll accounting and administration, including payroll reconciliations, payroll-related controls, and coordination with HR and third-party payroll providers.
Experience with any of the following systems: Netsuite, Concur, Prendio, FloQast,, ADP WorkForceNow.

Obsidian is committed to equitable and transparent pay practices.

The anticipated base salary range for this role is below. The actual base salary offered will be determined based on a combination of factors, including applicable qualifications, level of education, the depth of experience, unique skills, geographic location, internal equity, and/or business needs. The actual base salary offered will be in accordance with federal, state, and/or local wage requirements for the role’s location.

Our competitive compensation package includes an annual incentive bonus as a percentage of actual base salary and long-term incentives in the form of employee stock options, both of which are commensurate with the role’s level. We also offer a generous benefits package which includes comprehensive medical, dental, and vision coverage; company contributions to health savings and retirement accounts; ample paid time off; access to wellness programs; and rich career growth opportunities.

Anticipated Base Salary Range

$122,000—$149,500 USD

Obsidian is proud to be an equal opportunity employer, cultivating a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.