Expedition Medicines: Vice President, Finance

 COMPANY DESCRIPTION 

Expedition Medicines is a privately held, early-stage biotechnology company pioneering the emerging field of Protein Editing. At Expedition Medicines we create small molecules that edit protein structure and function to unlock presently undruggable targets and a broad array of therapeutic modalities. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to enable generative design. Expedition Medicines is backed by Flagship Pioneering, bringing their courage, vision, and resources to guide Expedition Medicines from platform validation to patient impact. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!  

The Role: 

Expedition Medicines is seeking a hands-on Vice President of Finance with deep experience in private biotech companies running both pre-clinical and clinical programs. The ideal candidate brings strong finance expertise, technical and operational accounting depth, proven leadership, and a demonstrated ability to build and deploy strategic finance processes at scale. This individual must be comfortable working independently in a resource-constrained environment while overseeing a lean finance and accounting function and also providing strategic financial guidance to the executive team. 

The Vice President of Finance will oversee all aspects of accounting, financial operations, and compliance while contributing meaningfully to corporate strategy and long-term planning. This is a key leadership role and is the primary steward of the company’s financial strategy, discipline, systems, and governance. 

Responsibilities:  

• Oversee and manage all accounting operations, financial reporting, and internal controls; ensure compliance with GAAP and applicable regulations, manage monthly, quarterly and annual close processes and tax and regulatory filings; initiate/lead financial statement audits 

• Partner with the CEO and leadership team to develop and refine the company’s financial strategy and long-term operating plan; provide scenario modeling within budgets, forecasts, and long-range planning models, and deliver capital allocation recommendations; support fundraising, investor relations, and board-level financial reporting 

• Implement and maintain innovative and scalable accounting and financial systems, processes and tools; oversee cash flow management, including tracking of R&D expenses, collaboration budgets and operational spend, and lead implementation of accounting and finance systems independent from the Flagship ecosystem 

• Manage external vendors — auditors, accounting consultants, tax advisors, and payroll providers — holding them to scope, budget, and timeline 

• Deploy AI accelerators across finance operations to improve speed, accuracy, and analytical capacity 

 

Qualifications: 

Essential 

• 15+ years of progressive finance and accounting experience, including senior leadership roles  

• Proven track record in a private life sciences/biotech company through growth and successful inflection points  

• Strong understanding of GAAP and biotech-specific accounting issues, including R&D accruals, intercompany transactions, and collaboration accounting 

• Experience in leading financial reporting , budgeting and long-range planning processes 

• Experience and comfort as an individual contributor as well as leading small teams, including external vendors 

• Demonstrated ability to work independently in a fast-paced, entrepreneurial environment 

Desirable 

• CPA or MBA strongly preferred  

• Experience supporting fundraising activities (venture capital, crossover, IPO readiness) 

• Understanding of and interest in utilizing AI and automation for finance  

• Familiarity with biopharma collaboration accounting and reporting as well as cost modeling for R&D programs 

 

Values and Behaviors: 

• Encourage respectful disagreement and cultivate open-minded, ego-free interactions to continuously push each other towards excellence 

• Seek out diverse perspectives; practice active listening and genuine curiosity to ensure all contributions are valued, regardless of source 

• Recognize the impact of your behavior, language, and attitudes; strive for balanced, meaningful exchanges that build mutual growth and understanding in all interactions 

• Use a company-first mindset to guide decision-making; prioritize team over individual success 

• Take calculated risks and challenge convention in the quest for exceptional outcomes 

 LOCATION: Cambridge, MA 

ABOUT FLAGSHIP PIONEERING 

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.   

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com. 

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. 

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. 

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. 

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. 

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The salary range for this role is $275,000 - $330,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Expedition Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Expedition Medicines's good faith estimate as of the date of publication and may be modified in the future.