Overview

We are seeking an Accounting Manager to play a key role in Alnylam’s core accounting operations, including monthly close, audits, systems, and application of accounting policies in accordance with U.S. GAAP. This hands‑on role requires strong attention to detail, sound judgment, and the ability to collaborate cross‑functionally in a dynamic environment.

Reporting to the Accounting Senior Manager, this position partners closely with the accounting team, internal stakeholders, and external advisors to help shape a high‑performing accounting function that supports the company’s growth.

This position is hybrid and will be primarily located in Cambridge, MA.

Responsibilities

Execute monthly, quarterly, and annual close activities, including journal entries, reconciliations, and analytical reviews.
Support accounting for R&D accruals, including preclinical and clinical trial accruals.
Partner with FP&A to ensure actuals align with forecasts; reconcile U.S. GAAP versus management reporting variances.
Assist with technical accounting efforts, including preparation of accounting memos and implementation of conclusions.
Support external reporting by providing timely and accurate input to the SEC reporting team.
Ensure effective internal controls over financial reporting in accordance with SOX requirements; assist with new control design as operations scale.
Support improvement and building of appropriate systems and processes to facilitate timely and accurate monthly accounting and financial close process
Contribute to improvements in accounting processes, systems, and close efficiency while maintaining high reporting quality.
Provide clear explanations of accounting results and adjustments to the Accounting Senior Manager to support the accounting close.
Support ad hoc projects and analyses, as needed.

Qualifications

Bachelor’s degree in accounting required, Master’s degree preferred.
Minimum of 4 years of relevant experience in public accounting (Big 4) and/or private industry required.
CPA license or completion of all CPA exams strongly preferred.
Global clinical accrual experience is strongly preferred.
Strong knowledge of U.S. GAAP and familiarity with SOX compliance.
SAP experience preferred.
Detail‑oriented, adaptable, and comfortable managing multiple priorities.
Advanced proficiency in Microsoft Excel and other Microsoft Office applications.

#LI-MH1 #LI-Hybrid

U.S. Pay Range

$117,300.00 - $158,700.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.