Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.

Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.

Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.

Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!

The Director, IT Business Partner — G&A & Finance Systems is the single accountable IT owner for Definium’s general & administrative (G&A) and finance application portfolio, and the primary bridge between Enterprise Technology and the Finance, Accounting, Procurement, People (HR), and in-scope R&D / Clinical functions. The role carries two responsibilities of company-wide significance: producing the IT control evidence underpinning Definium’s Sarbanes-Oxley (SOX) program, and serving as the IT operational lead for the governed roll-out of artificial intelligence (AI) across the company.

Key responsibilities

Business partnership & systems ownership

Serve as the primary IT business partner to Finance, Accounting, FP&A, Procurement, and People / HR — translating functional needs into a prioritized, business-aligned roadmap and advising on process improvement and automation

Own administration, configuration, and lifecycle management of the G&A / finance portfolio: NetSuite (ERP), Coupa (procure-to-pay), SAP Concur (T&E), BambooHR (HRIS), Greenhouse (ATS), Malbek (CLM), in-scope Veeva applications, and any newly identified applications as needed

Manage role design, user provisioning / deprovisioning, integrations, and data integrity under segregation-of-duties (SoD) and least-privilege principles; lead the migration of clinical systems from Medidata to Veeva eTMF / CTMS with the validation resource; and maintain configuration baselines and SOPs

Project & vendor / MSP management

Lead end-to-end delivery of new G&A / finance systems and enhancements — requirements, vendor selection, implementation, user-acceptance testing, go-live, and hypercare

Direct the Managed Service Providers (MSPs) and vendors performing build, configuration, and maintenance; manage statements of work, service levels, and escalations; and verify deliverables, including validation where applicable

SOX & IT general controls

Design, operate, and evidence IT general controls (ITGCs) — access management, change management, and IT operations — over financially-significant systems

Produce the IT control evidence supporting management’s assessment of internal control over financial reporting under SOX Section 404(a) for FY2026–FY2027, and prepare and dry-run the ITGC evidence for the first external-auditor attestation under 404(b) (built through FY2027 ahead of the FY2028 audit)

Execute periodic user-access reviews, SoD-conflict monitoring, and remediation tracking, partnering with Finance, Internal Audit, and external auditors as the IT control owner and evidence provider

Scope note: SOX program ownership and management’s attestation remain with Finance / Internal Audit. This role produces and operates the IT controls and evidence, does not self-attest, and performs privileged actions under documented compensating controls to preserve segregation of duties

Security, privacy & continuous improvement

Enforce access governance, SoD, and least-privilege in partnership with Information Security; support incident response; and ensure systems handling employee and financial personal data (e.g., BambooHR, Concur) are managed in line with applicable privacy laws (e.g., CCPA / CPRA)

Anticipate the system, control, and capacity needs of a rapidly scaling, soon-to-be-commercial organization; drive automation and integration; and maintain a centralized inventory of SaaS applications, licenses, and entitlements to eliminate redundant or dormant spend

AI enablement (enterprise-wide)

Serve as the IT operational lead for the safe, governed roll-out of AI across the entire company (not limited to G&A and Finance), executing under the authority and risk framework of Definium’s AI Oversight Group (AOG)

Operationalize AOG decisions — use-case intake and triage, tooling enablement, access and usage controls, monitoring, and user enablement — partnering with Legal, Quality, Compliance, Information Security, and the Data Protection Officer; escalate product-embedded AI / SaMD questions to the appropriate product-governance pathway

Required qualifications

Bachelor’s degree in Information Systems, Finance, Accounting, Business, or a related field; equivalent experience considered.

8+ years of progressive experience administering and delivering enterprise / financial systems, including hands-on ownership of a cloud ERP (NetSuite strongly preferred).

Demonstrated experience operating and evidencing ITGCs in a SOX environment at a publicly-traded company.

Working knowledge of procure-to-pay (Coupa), travel & expense (Concur), and HRIS (BambooHR), or comparable platforms.

Proven project management across full system-implementation lifecycles (including MSP and vendor management), with a strong command of SoD, least-privilege, and change-management disciplines and excellent stakeholder and executive communication skills.

Preferred qualifications

Life sciences, pharmaceutical, biotech, or other regulated-industry experience, including familiarity with GxP, 21 CFR Part 11, and EMA Annex 11, and hands-on Veeva administration (Clinical, Regulatory, Quality suites).

Experience supporting a pre-commercial company through commercial launch and rapid scaling, and leading enterprise AI enablement within a governance framework.

Relevant certifications (e.g., NetSuite Administrator / SuiteFoundation, PMP, CISA).

Compensation & posting information

The starting base pay range for this position is $203,632.00-233,500.00 with compensation determined based on several factors including skill set, years of experience, and geographic location.

Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including:

100% paid health benefits including Medical, Dental and Vision for you and your dependents
401(k) program with company match and vesting after the turn of the first month after your start date
Flexible time off
Generous parental leave and some fun fringe perks!